dataAdditive {frailtypack}

Simulated data as a gathering of clinical trials databases

Description

This contains simulated samples of 100 clusters with 100 subjects in each cluster, like a gathering of clinical trials databases. Two correlated centred gaussian random effects are generated with the same variance fixed at 0.3 and the covariance at -0.2. The regression coefficient \beta is fixed at -0.11. The percentage of right-censored data is around 30 percent which are generated from a uniform distribution on [1,150]. The baseline hazard function is considered as a simple Weibull.

Usage

data(dataAdditive)

Format

This data frame contains the following columns:

group

identification variable

t1

start of interval (=0, because left-truncated data are not allowed)

t2

end of interval (death or censoring time)

event

censoring status (0:alive, 1:death, as acensoring indicator

var1

dichotomous covariate (=0 or 1,as a treatment variable)

var2

dichotomous covariate (=0 or 1,as a treatment variable)

Source

V. Rondeau, S. Michiels, B.Liquet, and J.P. Pignon (2008). Investigating trial and treatment heterogeneity in an individual patient data meta-analysis of survival data by mean of the maximum penalized likelihood approach. Statistics in Medecine, 27, 1894-1910.