| pdlt_d1ph {ewoc} | R Documentation |
Generating a probability of DLT function based on the EWOC Proportional Hazards model
Description
Generating a probability of DLT function based on the EWOC Proportional Hazards model
Usage
pdlt_d1ph(rho, mtd, shape = NULL, theta, min_dose, max_dose, tau, distribution)
Arguments
rho |
a numerical value indicating the true value of the parameter rho. |
mtd |
a numerical value indicating the true value of the parameter mtd. |
shape |
a numerical value indicating the true value of the parameter shape. It is only necessary if 'distribution' = "weibull". |
theta |
a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD. |
min_dose |
a numerical value defining the lower bound of the support of the MTD. |
max_dose |
a numerical value defining the upper bound of the support of the MTD. |
tau |
a numerical value defining the period of time for a possible toxicity be observed. |
distribution |
a character establishing the distribution for the time of events. It can be defined as 'exponential' or 'weibull'. |
Value
A function with dose as an input and a probability based on the logistic regression and parameters as an output.
Examples
pdlt <- pdlt_d1ph(rho = 0.05, mtd = 40, theta = 0.33,
min_dose = 30, max_dose = 50,
tau = 10, distribution = "exponential")
pdlt(40)