mtd_rho_d1extended {ewoc}

Convert mtd to rho_1 and vice-versa

Description

Converting mtd to rho_1 given rho_0 for EWOC design using extended parametrization and vice-versa.

Usage

mtd_rho_d1extended(mtd = NULL, rho_1 = NULL, rho_0, theta, min_dose, max_dose)

Arguments

mtd

a numerical value defining the mtd value to be converted into rho_1 value.

rho_1

a numerical value defining the probability of DLT at the max_dose.

rho_0

a numerical value defining the probability of DLT at the min_dose.

theta

a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD.

min_dose

a numerical value defining the lower bound of the support of the MTD.

max_dose

a numerical value defining the upper bound of the support of the MTD.

Value

mtd a numerical value for the maximum tolerable dose.

rho_1 a numerical value for the probability of DLT at the max_dose.