average_toxicity {ewoc} | R Documentation |
Average Toxicity Number
Description
Calculate the Average Toxicity Number.
Usage
average_toxicity(dose, dose_set, true_prob, theta)
Arguments
dose |
a numerical matrix of assigned doses for each step of the trial (column) and for each trial (row). |
dose_set |
a numerical vector of allowable doses in the trial. |
true_prob |
a numerical vector of the true probabilities associated with 'dose_set'. |
theta |
a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD. |
Value
Average Toxicity Number.
References
Cheung, Y. K. (2011). Dose finding by the continual reassessment method. CRC Press.
[Package ewoc version 0.3.0 Index]