lmekin {coxme}R Documentation

Fit a linear mixed effects model


The lmekin function fits a linear mixed effects model, with random effects specified in the same structure as in the coxme function.


lmekin(formula, data, weights, subset, na.action, control,
varlist, vfixed, vinit, method = c("ML", "REML"),
x = FALSE, y = FALSE, model=FALSE,
random, fixed, variance, ...)



a two-sided formula with the response as the left hand side of a ~ operator and the fixed and random effects on the right.


an optional data frame containing the variables named in the formula.

subset, weights, na.action

further model specifications arguments as in lm; see there for details.


optional list of control options. See coxme.control for details.


the variance family to be used for each random term. If there are multiple terms it will be a list of variance functions. The default is coxmeFull. Alternatively it can be a list of matrices, in which case the coxmeMlist function is used.


optional named list or vector used to fix the value of one or more of the variance terms at a constant.


optional named list or vector giving suggested starting values for the variance.


fit using either maximum likelihood or restricted maximum likelihood


if TRUE the X matrix (fixed effects) is included in the output object


if TRUE the y variable is included in the output object


if TRUE the model frame is included in the output object

fixed, random, variance

In an earlier version of lmekin the fixed and random effects were separate arguments. These arguments are included for backwards compatability, but are depreciated. The variance argument is a depreciated alias for vfixed.


any other arguments are passed forward to coxme.control.


Let A= \sigma^2 B be the variance matrix of the random effects where \sigma^2 is the residual variance for the model. Internally the routine solves for the parameters of B, computing A at the end. The vinit and vfixed parmaters refer to B, however.

It is possible to specify certain models in lmekin that can not be fit with lme, in particular models with familial genetic effects, i.e., a kinship matrix, and hence the name of the routine. Using user-specified variance functions an even wider range of models is possible. For simple models the specification of the random effects follows the same form as the lmer function. For any model which can be fit by both lmekin and lmer, the latter routine would normally be prefered due to a much wider selection of post-fit tools for residuals, prediction and plotting.

Much of the underlying model code for specification and manipulation of the random effects is shared with the coxme routine. In fact lmekin was originally written only to provide a test routine for those codes, and no expectation that it would find wider utility.


An object of class lmekin.


Terry Therneau

See Also

lmekin.object, coxme


  data(ergoStool, package="nlme")  # use a data set from nlme 
  fit1 <- lmekin(effort ~ Type + (1|Subject), data=ergoStool)
  ## Not run: 
  # gives the same result
  fit2 <- lme(effort ~ Type, data=ergoStool, random= ~1|Subject,
## End(Not run) 

[Package coxme version 2.2-20 Index]