nform {colocPropTest}

Helper function to adjust LD parameter r for differential sample size between snps

Description

Estimate the r between effect estimates at snps which were genotyped on different sets of cases and controls. The adjusted r will be nform(...) * r (where r is the population correlation between snps).

Usage

nform(n0a, n1a, n0b, n1b, n0ab = pmin(n0a, n0b), n1ab = pmin(n1a, n1b))

Arguments

n0a

number of controls with data at snp a

n1a

number of cases with data at snp a

n0b

number of controls with data at snp b

n1b

number of cases with data at snp b

n0ab

number of controls with data at both snps a and b

n1ab

number of cases with data at both snps a and b

Value

proportionality constant that depends on sample size.