dob_to_pdr {breathtestcore}

Convert breath test DOB data to PDR data

Description

Convert DOB (delta-over-baseline) to PDR for 13C breath test. This is equation (4) in Sanaka, Yamamoto, Tsutsumi, Abe, Kuyama (2005) Wagner-Nelson method for analysing the atypical double-peaked excretion curve in the [13c]-octanoate gastric emptying breath test in humans. Clinical and experimental pharmacology and physiology 32, 590-594.

Usage

dob_to_pdr(
  dob,
  weight = 75,
  height = 180,
  mw = 167,
  purity_percent = 99.1,
  mg_substrate = 100
)

Arguments

dob

Delta-over-baseline vector in 0/00

weight

Body weight in kg; assumed 75 kg if missing

height

Body height in cm; assume 180 cm if missing

mw

Molecular weight, 83.023388 g/mol for acetate, 167 g/mol for octanoate. Can also be given as string "acetate" or "octanoate".

purity_percent

Purity in percent

mg_substrate

Substrate in mg

Value

PDR percent dose/h

Note

I have no idea where the factor 10 in equation (4) comes from, possibly from percent(PDR)/and DOB(0/00). In Kim and Camillieri, Stable isotope breath test and gastric emptying, page 207, a factor of 0.1123 instead of 0.01123 is used, without the factor 10. Which one is correct?

Examples

filename = btcore_file("350_20049_0_GERWithWeight.txt")
bid = read_breathid(filename)
bid$data$pdr1 = dob_to_pdr(bid$data$dob, weight=bid$weight, height=bid$height)

plot(bid$data$minute, bid$data$pdr1, main="points: from breath_id; line: computed",
type="l")
points(bid$data$minute, bid$data$pdr,col="red",type="p",pch=16)
#
# Check how far our computed pdr is from the stored pdr
var(bid$data$pdr1-bid$data$pdr)