obd.select {boinet}

Optimal biological dose selection

Description

Optimal biological dose (OBD) is selected by a method specified.

Usage

obd.select(
  probt, probe, method,
  phi, phi1, phi2, delta, delta1,
  tterm, eterm, stopT, stopE,
  w1, w2,
  plow.ast, pupp.ast, qlow.ast, qupp.ast,
  psi00, psi11)

Arguments

probt

Estimated toxicity probability.

probe

Estimated efficacy probability.

method

Method used for OBD selection.

phi

Target toxicity probability.

phi1

Lower bound of toxicity probability.

phi2

Upper bound of toxicity probability.

delta

Target efficacy probability.

delta1

Lower bound of efficacy probability.

tterm

Probability of meeting toxicity stopping criteria.

eterm

Probability of meeting efficacy stopping criteria.

stopT

Toxicity stopping criteria.

stopE

Efficacy stopping criteria.

w1

Weight for toxicity-efficacy trade-off.

w2

Weight for penalty imposed on toxic doses.

plow.ast

Lower threshold of toxicity linear truncated function.

pupp.ast

Upper threshold of toxicity linear truncated function.

qlow.ast

Lower threshold of efficacy linear truncated function.

qupp.ast

Upper threshold of efficacy linear truncated function.

psi00

Score for toxicity=no and efficacy=no.

psi11

Score for toxicity=yes and efficacy=yes.

Value

The obd.select returns an optimal biological dose.