multi.iso {boinet}

Model averaging of multiple unimodal isotopic regression

Description

Given the location of the mode to be at each dose level, the unimodal isotonically transformed values are calculated. A frequentist model averaging approach is used to obtain the estimated efficacy probability.

Usage

multi.iso(obs, n)

Arguments

obs

Number of patients with events.

n

Number of patients.

Value

The multi.iso returns a vector of estimated probabilities for each dose level.