get_deltamethod_std_err {biodosetools}

Get standard errors using delta method

Description

Delta method for approximating the standard error of a transformation g(X) of a random variable X = (x1, x2, ...), given estimates of the mean and covariance matrix of X.

Usage

get_deltamethod_std_err(
  fit_is_lq,
  variable = c("dose", "fraction_partial", "fraction_hetero"),
  mean_estimate,
  cov_estimate,
  protracted_g_value = NA,
  d0 = NA
)

Arguments

fit_is_lq

Whether the fit is linear quadratic (TRUE) or linear (FALSE).

variable

Variable resulting of the transformation g(X).

mean_estimate

The estimated mean of X.

cov_estimate

The estimated covariance matrix of X.

protracted_g_value

Protracted G(x) value.

d0

Survival coefficient of irradiated cells.

Value

Numeric value containing the standard error of the dose estimate.