print.threep3 {bcrm} | R Documentation |
Print information regarding the operating characteristics of a standard 3+3 design
Description
Print method for a 3+3 design specified using a threep3
.
Usage
## S3 method for class 'threep3'
print(x, tox.cutpoints = NULL, dose = NULL, ...)
Arguments
x |
An object of class "threep3" as returned by |
tox.cutpoints |
An optional argument passed to |
dose |
Optional vector of length |
... |
Further arguments passed to or from other methods |
Details
The following operating characteristics are printed for the standard 3+3 design:
- Sample size
Mean, minimum and maximum sample size of the design
- Experimentation proportion
Proportion of patients recruited to each dose, and to each true region of toxicity, on average
- Recommendation proportion
Proportion of 3+3 trials that would recommend each of the dose levels as the final maximum tolerated dose (see
threep3
for definition of the MTD), and the associated regions of true toxicity for the recommended MTDs- Average number of patients
The average number of patients dosed at each level
- Average number of DLTs
The average number of DLTs seen at each level
Author(s)
Michael Sweeting mjs212@medschl.cam.ac.uk (University of Cambridge, UK)
References
Sweeting M., Mander A., Sabin T. bcrm: Bayesian Continual Reassessment Method Designs for Phase I Dose-Finding Trials. Journal of Statistical Software (2013) 54: 1–26. http://www.jstatsoft.org/article/view/v054i13