BaetenEtAl2013 {bayesmeta}R Documentation

Ankylosing spondylitis example data


Numbers of cases (patients) and events (responders) in the placebo control groups of eight studies.




The data frame contains the following columns:

study character study label
year numeric publication year
events numeric number of responders
total numeric total number of patients


A study was conducted in order to investigate a novel treatment in ankylosing spondylitis (Baeten et al., 2013). The primary endpoint related to treatment response. In order to formulate an informative prior distribution for the response rate to be expected in the control group of the new study, a systematic review of previous studies was consulted (McLeod et al., 2007), and, after a meta-analysis of the estimated response probabilities, the predictive distribution for the new study's response probability was derived. The predictive distribution here constitutes the meta-analytic-predictive (MAP) prior distribution (Schmidli et al., 2014). The data set contains the relevant data from the eight “historical” studies' placebo groups.

Note that the original analysis (Baeten et al., 2013) involved a binomial model, and the resulting posterior predictive distribution was eventually approximated by a mixture of beta distributions.


D. Baeten et al. Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. The Lancet, 382(9906):1705-1713, 2013. doi: 10.1016/S0140-6736(13)61134-4.


C. McLeod et al. Adalimumab, etanercept, and infliximab for the treatment of ankylosing spondylitis: a systematic review and economic evaluation. Health Technology Assessment, 11(28), 2007. doi: 10.3310/hta11280.

H. Schmidli, S. Gsteiger, S. Roychoudhury, A. O'Hagan, D. Spiegelhalter, B. Neuenschwander. Robust meta-analytic-predictive priors in clinical trials with historical control information. Biometrics, 70(4):1023-1032, 2014. doi: 10.1111/biom.12242.

See Also

uisd, ess.


## Not run: 
# compute effect sizes (logarithmic odds) from the count data:
as <- escalc(xi=events, ni=total, slab=study,
             measure="PLO", data=BaetenEtAl2013)

# compute the unit information standard deviation (UISD):

# perform meta-analysis
# (using uniform priors for effect and heterogeneity):
bm <- bayesmeta(as)

# show results (log-odds):
forestplot(bm, xlab="log-odds", zero=NA)
# show results (odds):
forestplot(bm, exponentiate=TRUE, xlab="odds", zero=NA)

# show posterior predictive distribution --
# in terms of log-odds:
# in terms of odds:
logodds <- bm$summary[c(2,5,6), "theta"]
# in terms of probabilities:
(exp(logodds) / (exp(logodds) + 1))

# illustrate MAP prior density:
x <- seq(-3, 1, by=0.01)
plot(x, bm$dposterior(theta=x, predict=TRUE), type="l",
     xlab="log-odds (response)", ylab="posterior predictive density")
abline(h=0, v=0, col="grey")

## End(Not run)

[Package bayesmeta version 2.7 Index]