lgnbyuni {afthd}

Bayesian univariate analysis of AFT model with log normal distribution.

Description

Provides posterior estimates of AFT model with log normal distribution using Bayesian for univariate in high dimensional gene expression data. It also deals covariates with missing values.

Usage

lgnbyuni(m, n, STime, Event, nc, ni, data)

Arguments

m

Starting column number of covariates of study from high dimensional entered data.

n

Ending column number of covariates of study from high dimensional entered data.

STime

name of survival time in data

Event

name of event in data. 0 is for censored and 1 for occurrence of event.

nc

number of MCMC chain.

ni

number of MCMC iteration to update the outcome.

data

High dimensional gene expression data that contains event status, survival time and and set of covariates.

Details

This function deals covariates (in data) with missing values. Missing value in any column (covariate) is replaced by mean of that particular covariate. AFT model is log-linear regression model for survival time T_1 , T_2 ,..,T_n . i.e.,

log(T_i)= x_i'\beta +\sigma\epsilon_i ;~\epsilon_i \sim F_\epsilon (.)~which~is~iid

Where F_\epsilon is known cdf which is defined on real line. When baseline distribution is normal then T follows log normal distribution.

T \sim LN(x'\beta,1/\tau)

Value

Data frame is containing posterior estimates (Coef, SD, Credible Interval, Rhat, n.eff) of regression coefficient of selected covariates and deviance. Result shows together for all covariates chosen from column m to n.

Author(s)

Atanu Bhattacharjee, Gajendra Kumar Vishwakarma and Pragya Kumari

References

Prabhash et al(2016) <doi:10.21307/stattrans-2016-046>

See Also

lgnbymv, wbysuni, lgstbyuni

Examples

##
data(hdata)
lgnbyuni(10,12,STime="os",Event="death",2,10,hdata)
##