derive_var_anrind {admiral}

Derive Reference Range Indicator

Description

Derive Reference Range Indicator

Usage

derive_var_anrind(
  dataset,
  signif_dig = get_admiral_option("signif_digits"),
  use_a1hia1lo = FALSE
)

Arguments

dataset

Input dataset ANRLO, ANRHI, and AVAL are expected and if use_a1hia1lo is set to TRUE, A1LO and A1H1 are expected as well.

signif_dig

Number of significant digits to use when comparing values.

Significant digits used to avoid floating point discrepancies when comparing numeric values. See blog: How admiral handles floating points

use_a1hia1lo

A logical value indicating whether to use A1H1 and A1LO in the derivation of ANRIND.

Details

In the case that A1H1 and A1LO are to be used, ANRIND is set to:

• "NORMAL" if AVAL is greater or equal ANRLO and less than or equal ANRHI; or if AVAL is greater than or equal ANRLO and ANRHI is missing; or if AVAL is less than or equal ANRHI and ANRLO is missing

• "LOW" if AVAL is less than ANRLO and either A1LO is missing or AVAL is greater than or equal A1LO

• "HIGH" if AVAL is greater than ANRHI and either A1HI is missing or AVAL is less than or equal A1HI

• "LOW LOW" if AVAL is less than A1LO

• "HIGH HIGH" if AVAL is greater than A1HI

In the case that A1H1 and A1LO are not to be used, ANRIND is set to:

• "NORMAL" if AVAL is greater or equal ANRLO and less than or equal ANRHI; or if AVAL is greater than or equal ANRLO and ANRHI is missing; or if AVAL is less than or equal ANRHI and ANRLO is missing

• "LOW" if AVAL is less than ANRLO

• "HIGH" if AVAL is greater than ANRHI

Value

The input dataset with additional column ANRIND

See Also

BDS-Findings Functions that returns variable appended to dataset: derive_basetype_records(), derive_var_analysis_ratio(), derive_var_atoxgr(), derive_var_atoxgr_dir(), derive_var_base(), derive_var_chg(), derive_var_ontrtfl(), derive_var_pchg(), derive_var_shift()

Examples

library(tibble)
library(dplyr, warn.conflicts = FALSE)

vs <- tibble::tribble(
  ~USUBJID, ~PARAMCD, ~AVAL, ~ANRLO, ~ANRHI, ~A1LO, ~A1HI,
  "P01",       "PUL",    70,     60,    100,    40,   110,
  "P01",       "PUL",    57,     60,    100,    40,   110,
  "P01",       "PUL",    60,     60,    100,    40,   110,
  "P01",     "DIABP",   102,     60,     80,    40,    90,
  "P02",       "PUL",   109,     60,    100,    40,   110,
  "P02",       "PUL",   100,     60,    100,    40,   110,
  "P02",     "DIABP",    80,     60,     80,    40,    90,
  "P03",       "PUL",    39,     60,    100,    40,   110,
  "P03",       "PUL",    40,     60,    100,    40,   110
)

vs %>% derive_var_anrind(use_a1hia1lo = TRUE)
vs %>% derive_var_anrind(use_a1hia1lo = FALSE)