prev {TRD}

Calculate theoretical prevalence of disease

Description

Use 3 penetrance factors for genotype 0, 1 and 2 (additive model), ratio of maternal to paternal-induced disease risk for a heterozygous child, tranmission ratio of minor allele from mother and father to offspring, and minor allele frequency (MAF) to calculate the disease prevalence. Additive model means the genotype is the number of copies of minor allele that the individual carries assuming a bi-allelic locus. This genotype will be 0 for homozygous wild-type, 1 for heterozygous, and 2 for homozygous mutant. Minor allele normally refers to the disease allele, which has lower frequency than the alternative allele(s).

Usage

prev(f0, f1, f2, g, tmother, tfather, maf)

Arguments

f0

penetrance for individuals with genotype 0 (additive model)

f1

penetrance for individuals with genotype 1 (additive model)

f2

penetrance for individuals with genotype 2 (additive model)

g

Ratio of maternal- over paternal-induced disease risk

tmother

transmission ratio of minor allele from mother to child

tfather

transmission ratio of minor allele from father to child

maf

minor allele frequency

Value

d

disease prevalence

Author(s)

Lam Opal Huang

Examples

prev(0.1,0.2,0.3,1,0.5,0.5,0.1)