simu.VEGs {SCRIP}

SCRIP simulation for clustering analysis

Description

Simulate count data for clustering analysis by preserving variably expressed genes

Usage

simu.VEGs(
  counts.matrix,
  params = params,
  base_allcellmeans,
  mode = "GP-trendedBCV",
  nCells,
  nfeatures = 1000
)

Arguments

counts.matrix

data matrix required for simulation

params

SplatParams object containing parameters for the simulation

base_allcellmeans

base cell means specified directly for simulating counts

mode

"GP-commonBCV", "BP-commonBCV", "BP", "BGP-commonBCV" and "BGP-trendedBCV"

nCells

number of cells simulated

nfeatures

parameter required for FinalVariable function in Seurat package

Value

simulated read counts data