SCRIPsimDropout {SCRIP}

Simulate dropout

Description

A logistic function is used to form a relationship between the expression level of a gene and the probability of dropout, giving a probability for each gene in each cell. These probabilities are used in a Bernoulli distribution to decide which counts should be dropped.

Usage

SCRIPsimDropout(sim, params)

Arguments

sim

SingleCellExperiment to add dropout to.

params

SplatParams object with simulation parameters.

Value

SingleCellExperiment with simulated dropout and observed counts.