Power and Sample Size for (Bio)Equivalence Studies


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Documentation for package ‘PowerTOST’ version 1.5-6

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bib.CL Design matrices of period balanced incomplete block designs
CI.BE 1-2*alpha confidence interval given point estimate, CV, and n
CI.RatioF 1-2*alpha Fieller CI given point estimate, CV (, CVb) and n
CI2CV CV from a given Confidence interval
ct5.1 Sample Size Tables for the Classical 2x2 Crossover Design
ct5.2 Sample Size Tables for the Classical 2x2 Crossover Design
ct5.3 Sample Size Tables for the Classical 2x2 Crossover Design
ct5.4.1 Sample Size Tables for the Classical 2x2 Crossover Design
ct9.6.2 Sample Size Tables for the 2x2x3 Replicate Crossover Design
ct9.6.4 Sample Size Tables for the 2x4x4 Replicate Crossover Design
ct9.6.6 Sample Size Tables for the 2x2x3 Replicate Crossover Design
ct9.6.8 Sample Size Tables for the 2x4x4 Replicate Crossover Design
ctCW.III Sample Size Tables for the Parallel Group Design
ctSJ.VIII.10 Sample Size Tables for the Parallel Group Design
ctSJ.VIII.20 Sample Size Tables for the Parallel Group Design
CV2mse Helper functions
CV2se Helper functions
CVCL Confidence limits of a CV for log-normal data
CVfromCI CV from a given Confidence interval
CVp2CV Decompose CV(T) and CV(R) from 'pooled' CV of T/R
CVpooled Pooled CV from several studies
CVwRfromU CVwR from the upper expanded limit (ABEL)
data2x2 Sample Size Tables for the Classical 2x2 Crossover Design
data2x2x3 Sample Size Tables for the 2x2x3 Replicate Crossover Design
data2x4x4 Sample Size Tables for the 2x4x4 Replicate Crossover Design
data_parallel Sample Size Tables for the Parallel Group Design
defunct Removed functions in PowerTOST
deprecated Deprecated functions in PowerTOST
exppower.noninf Expected power of the non-inferiority test
exppower.TOST Expected power of the TOST procedure
expsampleN.noninf Sample size based on expected power for the non-inferiority test
expsampleN.TOST Sample size based on expected power
known.designs Show the 'known' designs
mse2CV Helper functions
OwensQ Owen's Q-function
OwensQOwen Owen's Q-function via repeated integration by parts
OwensT Owen's T-function
pa.ABE Power analysis for average bioequivalence (ABE)
pa.NTID Power analysis for scaled ABE for NTIDs
pa.NTIDFDA Power analysis for scaled ABE for NTIDs
pa.scABE Power analysis for scaled average bioequivalence (scABE)
plot.pwrA Power analysis for average bioequivalence (ABE)
power.2TOST Power for two simultaneous TOST procedures
power.dp Power of dose-proportionality studies evaluated via Power model
power.HVNTID (Empirical) Power for BE decision via FDA method for highly variable NTIDs
power.noninf Power of the one-sided non-inferiority t-test
power.NTID (Empirical) Power for BE decision via FDA method for NTIDs
power.NTIDFDA (Empirical) Power for BE decision via FDA method for NTIDs
power.RatioF Power for equivalence of the ratio of two means with normality on original scale
power.RSABE (Empirical) Power for BE decision via linearized scaled ABE criterion
power.RSABE2L.sds (Empirical) Power of BE Decision via Reference Scaled ABE
power.RSABE2L.sdsims (Empirical) Power of BE Decision via Reference Scaled ABE
power.scABEL (Empirical) Power of BE decision via scaled (widened) BE acceptance limits
power.scABEL.sds (Empirical) Power of BE decision via scaled (widened) BE acceptance limits
power.scABEL.sdsims (Empirical) Power of BE decision via scaled (widened) BE acceptance limits
power.TOST Power of the classical TOST procedure
power.TOST.sds Power calculation of the BE decision with models incorporating groups
power.TOST.sim Power of the TOST procedure obtained via simulations
print.CVp Pooled CV from several studies
print.pwrA Power analysis for average bioequivalence (ABE)
pvalue.TOST p-value(s) of the TOST procedure
pvalues.TOST p-value(s) of the TOST procedure
reg_const Constructor of an object with class 'regSet' containing the regulatory settings for ABEL
sampleN.2TOST Sample size based on power of two TOSTs
sampleN.dp Sample size estimation of dose-proportionality studies evaluated via the power model
sampleN.HVNTID Sample size estimation for BE decision via FDA method for highly variable (HV) narrow therapeutic index drugs (NTIDs)
sampleN.noninf Sample size for the non-inferiority t-test
sampleN.NTID Sample size estimation for BE decision via the FDA's method for narrow therapeutic index drugs (NTIDs)
sampleN.NTIDFDA Sample size estimation for BE decision via the FDA's method for narrow therapeutic index drugs (NTIDs)
sampleN.RatioF Sample size for equivalence of the ratio of two means with normality on original scale
sampleN.RSABE Sample size estimation for BE decision via linearized scaled ABE criterion
sampleN.RSABE2L.sds Sample size estimation for BE Decision via Reference Scaled ABE
sampleN.RSABE2L.sdsims Sample size estimation for BE Decision via Reference Scaled ABE
sampleN.scABEL Sample size estimation for BE decision via scaled (expanded) BE acceptance limits
sampleN.scABEL.ad Sample size estimation for ABEL and iteratively adjusted alpha
sampleN.scABEL.sds Sample size estimation for BE decision via scaled (expanded) BE acceptance limits
sampleN.scABEL.sdsims Sample size estimation for BE decision via scaled (expanded) BE acceptance limits
sampleN.TOST Sample size based on power of TOST
scABEL Scaled (widened) BE Acceptance Limits
scABEL.ad Iteratively adjusted alpha for ABEL
se2CV Helper functions
type1error.2TOST Type I error rate for two simultaneous TOST procedures
U2CVwR CVwR from the upper expanded limit (ABEL)