feps.add {PopED} | R Documentation |
RUV model: Additive .
Description
This is a residual unexplained variability (RUV) model function that encodes the model described above.
The function is suitable for input to the create.poped.database
function using the
fError_file
argument.
Usage
feps.add(model_switch, xt, parameters, epsi, poped.db)
Arguments
model_switch |
a vector of values, the same size as |
xt |
a vector of independent variable values (often time). |
parameters |
A named list of parameter values. |
epsi |
A matrix with the same number of rows as the |
poped.db |
a poped database. This can be used to extract information that may be needed in the model file. |
Value
A list consisting of:
y the values of the model at the specified points.
poped.db A (potentially modified) poped database.
See Also
Other models:
feps.add.prop()
,
feps.prop()
,
ff.PK.1.comp.oral.md.CL()
,
ff.PK.1.comp.oral.md.KE()
,
ff.PK.1.comp.oral.sd.CL()
,
ff.PK.1.comp.oral.sd.KE()
,
ff.PKPD.1.comp.oral.md.CL.imax()
,
ff.PKPD.1.comp.sd.CL.emax()
Other RUV_models:
feps.add.prop()
,
feps.prop()
Examples
library(PopED)
## find the parameters that are needed to define from the structural model
ff.PK.1.comp.oral.sd.KE
## -- parameter definition function
## -- names match parameters in function ff
sfg <- function(x,a,bpop,b,bocc){
parameters=c(KE=bpop[1]*exp(b[1]),
V=bpop[2]*exp(b[2]),
KA=bpop[3]*exp(b[3]),
Favail=bpop[4],
DOSE=a[1])
return(parameters)
}
## -- Define initial design and design space
poped.db <- create.poped.database(ff_fun=ff.PK.1.comp.oral.sd.KE,
fg_fun=sfg,
fError_fun=feps.add,
bpop=c(KE=0.15/8, V=8, KA=1.0, Favail=1),
notfixed_bpop=c(1,1,1,0),
d=c(KE=0.07, V=0.02, KA=0.6),
sigma=1,
groupsize=32,
xt=c( 0.5,1,2,6,24,36,72,120),
minxt=0,
maxxt=120,
a=70)
## create plot of model without variability
plot_model_prediction(poped.db)
## evaluate initial design
FIM <- evaluate.fim(poped.db)
FIM
det(FIM)
get_rse(FIM,poped.db)