evaluate_design {PopED}

Evaluate a design

Description

This function evaluates the design defined in a poped database.

Usage

evaluate_design(poped.db, ...)

Arguments

poped.db

A poped database

...

Extra parameters passed to calc_ofv_and_fim and get_rse

Value

A list of elements evaluating the current design.

See Also

Other evaluate_design: evaluate.fim(), evaluate_power(), get_rse(), model_prediction(), plot_efficiency_of_windows(), plot_model_prediction()

Examples

library(PopED)

############# START #################
## Create PopED database
## (warfarin example)
#####################################

## Warfarin example from software comparison in:
## Nyberg et al., "Methods and software tools for design evaluation 
##   for population pharmacokinetics-pharmacodynamics studies", 
##   Br. J. Clin. Pharm., 2014. 

## find the parameters that are needed to define from the structural model
ff.PK.1.comp.oral.sd.CL

## -- parameter definition function 
## -- names match parameters in function ff
sfg <- function(x,a,bpop,b,bocc){
  parameters=c(CL=bpop[1]*exp(b[1]),
               V=bpop[2]*exp(b[2]),
               KA=bpop[3]*exp(b[3]),
               Favail=bpop[4],
               DOSE=a[1])
  return(parameters) 
}

## -- Define model, parameters, initial design
poped.db <- create.poped.database(ff_fun=ff.PK.1.comp.oral.sd.CL,
                                  fg_fun=sfg,
                                  fError_fun=feps.prop,
                                  bpop=c(CL=0.15, V=8, KA=1.0, Favail=1), 
                                  notfixed_bpop=c(1,1,1,0),
                                  d=c(CL=0.07, V=0.02, KA=0.6), 
                                  sigma=c(prop=0.01),
                                  groupsize=32,
                                  xt=c( 0.5,1,2,6,24,36,72,120),
                                  a=c(DOSE=70))

############# END ###################
## Create PopED database
## (warfarin example)
#####################################

evaluate_design(poped.db)