| admiss {PlatformDesign} | R Documentation |
Find the admissible set in a two-period K+M-experimental arm platform design with delayed arms
Description
Find the admissible set of the (n2, n0_2) pairs, given n1, n0_1, nt, ntrt and S.
Usage
admiss(n1, n0_1, nt, ntrt, S)
Arguments
n1 |
the sample size in each of the K experimental arms in the K-experimental arm trial |
n0_1 |
the sample size of the common control arm in the K-experimental arm trial |
nt |
the number of patients already enrolled on each of the K initial experimental arms when the new arms are added |
ntrt |
the number of experimental arms in the K+M-experimental arm trial, i.e, K+M |
S |
the upper limit of the total sample size for the K+M-experimental arm trial. It usually takes the value of the sum of the sample sizes of two separate clinical trials (one with K and another with M experimental arms, each having one control arm). The total sample size of K (or M)-arm trial can be calculated using function one_stage_multiarm(). |
Details
Given n1, n0_1, nt, ntrt and S, using three constraints to find the admissible set of the (n2, n0_2) pairs. See the vignettes for details.
Value
a dataframe which contains all candidate values of n2 and n0_2 in its first and second column, respectively
Examples
admiss(n1=101, n0_1=143, nt=30, ntrt=4, S=690)