RunAdaptiveEffToxTrialCORR {Phase12Compare}

Simulates utility based Efftox trials

Description

Simulates utility based Efftox trials

Usage

RunAdaptiveEffToxTrialCORR(
  DoseStart,
  Dose,
  Hypermeans,
  Hypervars,
  UT,
  PiLim,
  ProbLim,
  cohort,
  NET,
  NF,
  B,
  nSims,
  PMAT
)

Arguments

DoseStart

Dose level to START the EFF-Tox Trial

Dose

Vector of Doses considered in the trial

Hypermeans

6 vector of prior means

Hypervars

6 vector of prior standard deviations

UT

2x2 matrix of utilities corresponding to the four binary bivariate (toxicity, efficacy) events.

PiLim

2 vector of acceptable limits

ProbLim

2 vector of cutoff for acceptabilities

cohort

Cohort size

NET

Maximum Sample size to run the EFFtox Trial, must be divisible by cohort

NF

Minimum sample size to begin adaptive randomization, must be divisible by count

B

Number of reps to perform in MCMC

nSims

Number of Simulated trials to run.

PMAT

Contains TRUE pi00,pi10, pi01, pi11 for each dose

Value

Trial simulation results to be processed for operating characteristics summaries.