Design and Monitoring of Survival Trials Accounting for Complex Situations

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Documentation for package ‘PWEALL’ version 1.3.0.1

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PWEALL-package Design and Monitoring of Survival Trials Accounting for Complex Situations
cp Conditional power given observed log hazard ratio
cpboundary The stopping boundary based on the conditional power criteria
cpstop The stopping probability based on the stopping boundary
fourhr A utility functon
hxbeta A function to calculate the beta-smoothed hazard rate
innercov A utility function to calculate the inner integration of the overall covariance
innervar A utility function to calculate the inner integration of the overall variance
instudyfindt calculate the timeline in study when some or all subjects have entered
ovbeta calculate the overall log hazard ratio
overallcov calculate the overall covariance
overallcovp1 calculate the first part of the overall covariance
overallcovp2 calculate the other parts of the overall covariance
overallvar calculate the overall variance
pwe Piecewise exponential distribution: hazard, cumulative hazard, density, distribution, survival
PWEALL Design and Monitoring of Survival Trials Accounting for Complex Situations
pwecx Various function for piecewise exponential distribution with crossover effect
pwecxcens Integration of the density of piecewise exponential distribution with crossover effect and the censoring function
pwecxpwu Integration of the density of piecewise exponential distribution with crossover effect, censoring and recruitment function
pwecxpwufindt calculate the timeline when certain number of events accumulates
pwecxpwuforvar calculate the utility function used for varaince calculation
pwefv2 A utility function
pwefvplus A utility functon
pwepower Calculating the powers of various the test statistics for superiority trials
pwepowereq Calculating the powers of various the test statistics for equivalence trials
pwepowerfindt Calculating the timepoint where a certain power of the specified test statistics is obtained
pwepowerni Calculating the powers of various the test statistics for non-inferiority trials
pwesim simulating the test statistics
pwu Piecewise uniform distribution: distribution
qpwe Piecewise exponential distribution: quantile function
qpwu Piecewise uniform distribution: quantile function
rmstcov Calculation of the variance and covariance of estimated restricted mean survival time
rmsth Estimate the restricted mean survival time (RMST) and its variance from data
rmstpower Calculate powers at different cut-points based on difference of restricted mean survival times (RMST)
rmstpowerfindt Calculating the timepoint where a certain power of mean difference of RMSTs is obtained
rmstsim simulating the restricted mean survival times
rmstutil A utility function to calculate the true restricted mean survival time (RMST) and its variance account for delayed treatment, discontinued treatment and non-uniform entry
rpwe Piecewise exponential distribution: random number generation
rpwecx Piecewise exponential distribution with crossover effect: random number generation
rpwu Piecewise uniform distribution: random number generation
spf A utility function
wlrcal A utility function to calculate the weighted log-rank statistics and their varainces given the weights
wlrcom A function to calculate the various weighted log-rank statistics and their varainces
wlrutil A utility function to calculate some common functions in contructing weights