D_weight_2 {Opt5PL}

The second derivative of the D-optimality criterion w.r.t the model parameters

Description

The second derivative of the D-optimality criterion with respect to the model parameters. This is a sub-function of D_weight to run one iteration of Newton-Raphson method.

Usage

D_weight_2(q, W, T1, T2, T3, X, inv1, inv2, inv3)

Arguments

q

A numeric vector. User select weights defined in the function RDOPT

W

A numeric vector. The first K-1 weights for a given design

T1

A numeric vector. Model parameter values for the 3PL model

T2

A numeric vector. Model parameter values for the 4PL model

T3

A numeric vector. Model parameter values for the 5PL model

X

A numeric vector. K dose levels for a given design

inv1

A numeric matrix. Inverse information matrix for the 3PL model

inv2

A numeric matrix. Inverse information matrix for the 4PL model

inv3

A numeric matrix. Inverse information matrix for the 5PL model