DD1 {Opt5PL}

Computing each element of the function c_weight_2

Description

This function computes each element of the matrix function c_weight_2 which is the second derivative of the c-optimality criterion with respect to the model parameters.

Usage

DD1(T, x1, x2, xl, inv, p, order)

Arguments

T

A numeric vector. Model parameter values

x1

A numeric. ith dose level for a given design

x2

A numeric. jth dose level for a given design

xl

A numeric. last dose level for a given design

inv

A numeric matrix. Inverse of the information matrix

p

A numeric. Define EDp

order

numeric. The number of model paraemters