D1 {Opt5PL}

Computing each element of the function c_weight_1

Description

This function computes each element of the vector function c_weight_1 which is the first derivative of the c-optimality criterion with respect to the model parameters.

Usage

D1(T, x, xl, inv, p, order)

Arguments

T

A numeric vector. Model parameter values

x

A numeric. ith dose level for a given design

xl

A numeric. last dose level for a given design

inv

A numeric matrix. Inverse of the information matrix

p

A numeric. Define EDp

order

numeric. The number of model paraemters