| hist_combo2 {OncoBayes2} | R Documentation |
Dataset: historical data on two single-agents to inform a combination study
Description
One of two datasets from the application described in Neuenschwander et al
(2016). The risk of DLT is to be studied as a function of dose for two drugs,
drug A and drug B. Historical information on the toxicity profiles of these
two drugs is available from single agent trials trial_A and trial_B.
A second dataset codata_combo2 is available from this application,
which includes additional dose-toxicity data from trial_AB and IIT of the
combination of Drugs A and B.
Usage
hist_combo2
Format
A tibble with 11 rows and 5 variables:
- group_id
study
- drug_A
dose of Drug A
- drug_B
dose of Drug B
- num_patients
number of patients
- num_toxicities
number of DLTs
- cohort_time
cohort number of patients
References
Neuenschwander, B., Roychoudhury, S., & Schmidli, H. (2016). On the use of co-data in clinical trials. Statistics in Biopharmaceutical Research, 8(3), 345-354.