MaxLik-class {MendelianRandomization}

MaxLik Class

Description

An object containing the estimate produced using the maximum-likelihood method as well as various statistics.

Slots

Model

The model used for estimation: fixed-effect ("fixed") or random-effects ("random").

Exposure

The name of the exposure variable.

Outcome

The name of the outcome variable.

Correlation

The matrix of correlations between genetic variants.

Psi

The correlations between genetic associations with the exposure and with the outcome.

Estimate

The causal point estimate from the inverse-variance weighted method.

StdError

The standard error associated with Estimate.

CILower

The lower bound of the confidence interval for Estimate based on StdError.

CIUpper

The upper bound of the confidence interval for Estimate based on StdError.

Alpha

The significance level used in constructing the confidence interval (default is 0.05).

Pvalue

P-value associated with the causal estimate.

SNPs

The number of SNPs that were used in the calculation.

RSE

The estimated residual standard error from the regression model.

Heter.Stat

Heterogeneity statistic (likelihood ratio statistic) and associated p-value: the null hypothesis is that all genetic variants estimate the same causal parameter; rejection of the null is an indication that one or more variants may be pleiotropic.