MVEgger-class {MendelianRandomization}

MVEgger Class

Description

An object containing the estimates produced using the multivariable MR-Egger method as well as various statistics.

Slots

Model

Model always takes the value random, as only random-effects analyses are permitted.

Orientate

The number of the risk factor that genetic associations are orientated to. The default value is 1, meaning that genetic associations with the first risk factor are set to be positive.

Exposure

The names of the exposure variables.

Outcome

The name of the outcome variable.

Correlation

The matrix of correlations between genetic variants.

Estimate

The causal estimates from the inverse-variance weighted method.

StdError.Est

The standard errors associated with Estimate.

CILower.Est

The lower bounds of the confidence interval for Estimate based on StdError.

CIUpper.Est

The upper bounds of the confidence interval for Estimate based on StdError.

Pvalue.Est

P-value associated with the causal estimate.

Intercept

The intercept estimate from the MR-Egger method. Under the InSIDE assumption, the intercept represents the average pleiotropic effect (average direct effect on the outcome) of a genetic variant. If the intercept differs from zero, this is evidence that the genetic variants are not all valid instruments; specifically, there is directional pleiotropy.

StdError.Int

The standard error associated with Intercept.

CILower.Int

The lower bound of the confidence interval for Intercept based on StdError.Int.

CIUpper.Int

The upper bound of the confidence interval for Estimate based on StdError.Int.

Pvalue.Int

P-value associated with the intercept.

Alpha

The significance level used in constructing the confidence interval (default is 0.05).

SNPs

The number of SNPs that were used in the calculation.

RSE

The estimated residual standard error from the regression model.

Heter.Stat

Heterogeneity statistic (Cochran's Q statistic) and associated p-value: the null hypothesis is that all genetic variants estimate the same causal parameter; rejection of the null is an indication that one or more variants may be pleiotropic.