MRConMix-class {MendelianRandomization}

MRConMix Class

Description

An object containing the estimate produced using the contamination mixture method as well as various statistics.

Slots

Exposure

The names of the exposure variables.

Outcome

The name of the outcome variable.

Psi

The value of the standard deviation of the distribution of invalid estimands (default is 1.5 times the standard deviation of the ratio estimates).

Estimate

The causal estimate from the contamination mixture method.

CIRange

The confidence interval for Estimate based on a grid search.

CILower

The lower limit of the confidence interval. If the confidence interval contains multiple ranges, then lower limits of all ranges will be reported.

CIUpper

The upper limit of the confidence interval. If the confidence interval contains multiple ranges, then upper limits of all ranges will be reported.

CIMin

The smallest value used in the search to find the confidence interval.

CIMax

The largest value used in the search to find the confidence interval.

CIStep

The step size used in the search to find the confidence interval.

Pvalue

The p-value associated with the estimate calculated using the likelihood function and a chi-squared distribution.

Valid

The numbers of genetic variants that were considered valid instruments at the causal estimate.

ValidSNPs

The names of genetic variants that were considered valid instruments at the causal estimate.

Alpha

The significance level used in constructing the confidence interval (default is 0.05).

SNPs

The number of SNPs that were used in the calculation.