| gamtable1 {LW1949} | R Documentation |
Fit a smooth GAM to Table 1 of Litchfield and Wilcoxon (1949)
Description
Fit a smooth GAM function to replace looking up values in Table 1 of Litchfield and Wilcoxon (1949).
Usage
gamtable1()
Details
Note that for an expected value of 37 Table 1 gives a corrected value of
9.4, but for an expected value of 63 it gives a corrected value of 90.5.
To ensure that both values add to 100, I used corrected values of 9.45
and 90.55. The expected and corrected values from Table 1 are then used
to build a GAM model, which is used as input to the
correctval function.
Value
A gamObject that can be used to predict the corrected values
(as proportions) from distexpprop5,
the distance between the expected values (as proportions) and 0.5
References
Litchfield, JT Jr. and F Wilcoxon. 1949. A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96(2):99-113. [link].
Examples
fit <- gamtable1()
summary(fit)
plot(fit)