| simulated_HELIX_data {LUCIDus} | R Documentation |
A simulated HELIX dataset for LUCID
Description
The Human Early-Life Exposome (HELIX) project is multi-center research project that aims to characterize early-life environmental exposures and associate these with omics biomarkers and child health outcomes (Vrijheid, 2014. doi: 10.1289/ehp.1307204). We used a subset of HELIX data from Exposome Data Challenge 2021 (hold by ISGlobal) as an example to illustrate LUCID model.
Usage
simulated_HELIX_data
Format
A list with 4 matrices corresponding to exposures (G), omics data (Z), outcome (Y) and covariates (CoY), a total of 420 observations
- exposure
1 exposures measuring the maternal exposure to utero mercury.
- omics
10 methylomics, 10 transcriptomics, 10 miRNA
- outcome
A continuous outcome as an indicator of metabolic-dysfunciton-associated fatty liver disease (MAFLD)
- covariate
3 covariates including fish_preg_ter, child sex, maternal age