createSimulationSettings {EvidenceSynthesis}

Create simulation settings

Description

Create an object specifying a simulation. Currently only Cox proportional hazard models are supported.

Usage

createSimulationSettings(
  nSites = 5,
  n = 10000,
  treatedFraction = 0.2,
  nStrata = 10,
  minBackgroundHazard = 2e-07,
  maxBackgroundHazard = 2e-05,
  hazardRatio = 2,
  randomEffectSd = 0
)

Arguments

nSites

Number of database sites to simulate.

n

Number of subjects per site. Either a single number, or a vector of length nSites.

treatedFraction

Fraction of subjects that is treated. Either a single number, or a vector of length nSites.

nStrata

Number of strata per site. Either a single number, or a vector of length nSites.

minBackgroundHazard

Minimum background hazard. Either a single number, or a vector of length nSites.

maxBackgroundHazard

Maximum background hazard. Either a single number, or a vector of length nSites.

hazardRatio

Hazard ratio.

randomEffectSd

Standard deviation of the log(hazardRatio). Fixed effect if equal to 0.

Value

An object of type simulationSettings, to be used in the simulatePopulations() function.

See Also

simulatePopulations

Examples

settings <- createSimulationSettings(nSites = 1, hazardRatio = 2)
populations <- simulatePopulations(settings)

# Fit a Cox regression for the simulated data site:
cyclopsData <- Cyclops::createCyclopsData(Surv(time, y) ~ x + strata(stratumId),
  data = populations[[1]],
  modelType = "cox"
)
cyclopsFit <- Cyclops::fitCyclopsModel(cyclopsData)
coef(cyclopsFit)

# (Estimates in this example will vary due to the random simulation)