| freq_binom_one_landemets {EurosarcBayes} | R Documentation |
Single arm, two stage, Binomial sample size calculator
Description
Sample size calculation for single arm, multistage trials using the alpha spending approach to reduce type I and type II error rates. This implimentation uses the O'Brien-Fleming alpha spending function for this purpose.
Usage
freq_binom_one_landemets(reviews, p0, p1, r=c(p0,p1),
alpha=0.1, beta=0.1, prior.a=0, prior.b=0)
Arguments
reviews |
A vector of the number of patients to perform interim analysis at |
p0 |
Probability of success under the H0 |
p1 |
Probability of success under the H1 |
r |
A vector of probabilities used to perform simulations from |
alpha |
The largest allowed value for the frequentist type one error |
beta |
The smallest allowed value for the frequentist type two error |
prior.a, prior.b |
Prior parameters for the beta prior |
Value
Returns an object of class trialDesign_binom_one
References
DeMets, D. L. and G. Lan (1995). The alpha spending function approach to interim data analyses. Cancer Treat Res 75: 1-27.
O'Brien, P. C. and T. R. Fleming (1979). A Multiple Testing Procedure for Clinical Trials. Biometrics 35(3): 549-556.
Examples
reviews=c(11,22,33,44)
p0=0.2
p1=0.35
r=c(0.2,0.35)
alpha=0.1
beta=0.2
freq_binom_one_landemets(reviews,p0,p1,r,alpha,beta)