BrCa {Epi}

Clinical status, relapse, metastasis and death in 2982 women with breast cancer.

Description

This dataset is a transformation of the example dataset used by Crowther and Lambert in their multistate paper.

Usage

data(BrCa)

Format

A data frame with 2982 observations on the following 17 variables:

pid

Person-id; numeric

year

Calendar year of diagnosis

age

Age at diagnosis

meno

Menopausal status; a factor with levels pre post

size

Tumour size; a factor with levels <=20 mm >20-50 mm >50 mm

grade

Tumour grade; a factor with levels 2 3

nodes

Number of positive lymph nodes, a numeric vector

pr

Progesteron receptor level

pr.tr

Transformed progesteron level

er

Estrogen receptor level

hormon

Hormon therapy at diagnosis; a factor with levels no yes

chemo

Chemotherapy treatment; a factor with levels no yes

tor

Time of relapse, years since diagnosis

tom

Time of metastasis, years since diagnosis

tod

Time of death, years since diagnosis

tox

Time of exit from study, years since diagnosis

xst

Vital status at exit; a factor with levels Alive Dead

Details

The dataset has been modified to contain the times (since diagnosis) of the events of interest, to comply with the usual structure of data.

Source

The original data were extracted from: http://fmwww.bc.edu/repec/bocode/m/multistate_example.dta, this is modified representation of the same amount of information.

References

The data were used as example in the paper by Crowther and Lambert: Parametric multistate survival models: Flexible modelling allowing transition-specific distributions with application to estimating clinically useful measures of effect differences; Stat Med 36 (29), pp 4719-4742, 2017. (No, it is not the paper, just the title.)

A parallel analysis using the Lexis machinery is available as: http://bendixcarstensen.com/AdvCoh/papers/bcMS.pdf

Examples

data(BrCa)