mhc {Biostatistics}R Documentation

MHC promiscuity and pathogen diversity data

Description

Data relating the breadth of the MHC response for the HLA-DRB1 MHC gene from a number of populations worldwide, and an estimate of the diversity of intracellular and extracellular pathogens that the population is exposed to

Usage

data("mhc")

Format

A data frame with 28 observations on the following 4 variables.

Population

Population identifier

Extracellular

Diversity of extracellular pathogens

Intracellular

Diversity of intracellular pathogens

Promiscuity_in_vitro

Estimated range of epitopes that the MHC can bind to

Source

https://doi.org/10.1371/journal.pbio.3000131.s017

References

Manczinger, M., Boross, G., Kemeny, L., Muller, V., Lenz, T.L., Papp, B. & Pal, C. (2019) Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations. PLoS biology, 17, e3000131.

Examples

data(mhc)
str(mhc)

[Package Biostatistics version 1.0.3 Index]