| BeeGUTS-package {BeeGUTS} | R Documentation |
'BeeGUTS' package; a package to perform GUTS modelling for Bee experiments.
Description
Provide tools to analyse the survival toxicity tests performed for bee species. It can be used to fit a Toxicokinetic-Toxicodynamic (TKTD) model adapted for bee standard studies (acute oral, acute contact, and chronic oral studies). The TKTD model used is the General Unified Threshold model of Survival (GUTS).
The package follows the concept and assumptions presented in Baas et al (submitted)
References
Baas, J., Goussen, B., Miles, M., Preuss, T.G., Roessing, I. (submitted). BeeGUTS – new integrative TKTD model for honey bees approach moving from single point estimates of toxicity and exposure to a holistic link between exposure and effect.
Jager, T., Albert, C., Preuss, T.G. and Ashauer, R. (2011). General Unified Threshold model of Survival - a toxicokinetic-toxicodynamic framework for ecotoxicology. doi:10.1021/es103092a
Jager, T. and Ashauer, R. (2018). Modelling survival under chemical stress. A comprehensive guide to the GUTS framework. Version 1.0 https://leanpub.com/guts_book
EFSA PPR Scientific Opinion (2018). Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms. https://www.efsa.europa.eu/en/efsajournal/pub/5377
Stan Development Team (2020). RStan: the R interface to Stan. R package version 2.21.2. https://mc-stan.org