R: Select the maximum tolerated dose (MTD) for single agent...

select.mtd {BOIN}

R Documentation

Select the maximum tolerated dose (MTD) for single agent trials

Description

Select the maximum tolerated dose (MTD) when the single-agent trial is completed

Usage

select.mtd(target, npts, ntox, cutoff.eli=0.95, extrasafe=FALSE, offset=0.05,
                 boundMTD=FALSE,p.tox=1.4*target)

Arguments

`target`	the target DLT rate
`npts`	a vector containing the number of patients treated at each dose level
`ntox`	a vector containing the number of patients who experienced dose-limiting toxicity at each dose level
`cutoff.eli`	the cutoff to eliminate overly toxic doses for safety. We recommend the default value of (`cutoff.eli=0.95`) for general use.
`extrasafe`	set `extrasafe=TRUE` to impose a more strict stopping rule for extra safety
`offset`	a small positive number (between `0` and `0.5`) to control how strict the stopping rule is when `extrasafe=TRUE`. A larger value leads to a more strict stopping rule. The default value `offset=0.05` generally works well.
`boundMTD`	set `boundMTD=TRUE` to impose the condition: the isotonic estimate of toxicity probability for the selected MTD must be less than de-escalation boundary.
`p.tox`	the lowest toxicity probability that is deemed overly toxic such that deescalation is required. The default value is `p.tox=1.4*target`.

Details

select.mtd() selects the MTD based on isotonic estimates of toxicity probabilities. select.mtd() selects as the MTD dose j^*, for which the isotonic estimate of the DLT rate is closest to the target. If there are ties, we select from the ties the highest dose level when the estimate of the DLT rate is smaller than the target, or the lowest dose level when the estimate of the DLT rate is greater than the target. The isotonic estimates are obtained by the pooled-adjacent-violators algorithm (PAVA) (Barlow, 1972).

Value

select.mtd() returns (1) target toxicity probability ($target), (2) selected MTD ($MTD), (3) isotonic estimate of the DLT probablity at each dose and associated 95\% credible interval ($p_est), and (4) the probability of overdosing defined as Pr(toxicity>\code{target}|data) ($p_overdose)

Note

The MTD selection and dose escalation/deescalation rule are two independent components of the trial design. When appropriate, another dose selection procedure (e.g., based on a fitted logistic model) can be used to select the MTD after the completion of the trial using the BOIN design.

Author(s)

Suyu Liu, Yanhong Zhou, and Ying Yuan

References

Liu S. and Yuan, Y. (2015). Bayesian Optimal Interval Designs for Phase I Clinical Trials, Journal of the Royal Statistical Society: Series C, 64, 507-523.

Yan, F., Zhang, L., Zhou, Y., Pan, H., Liu, S. and Yuan, Y. (2020).BOIN: An R Package for Designing Single-Agent and Drug-Combination Dose-Finding Trials Using Bayesian Optimal Interval Designs. Journal of Statistical Software, 94(13),1-32.<doi:10.18637/jss.v094.i13>.

Yuan Y., Hess K.R., Hilsenbeck S.G. and Gilbert M.R. (2016). Bayesian Optimal Interval Design: A Simple and Well-performing Design for Phase I Oncology Trials, Clinical Cancer Research, 22, 4291-4301.

Examples


### select the MTD for BOIN single agent trial
n <- c(3, 3, 15, 9, 0)
y <- c(0, 0, 4, 4, 0)
selmtd <- select.mtd(target=0.3, npts=n, ntox=y)
summary(selmtd)
plot(selmtd)

[Package BOIN version 2.7.2 Index]