X_sampling {BICORN}

Transcription Factor Activity Sampling Function

Description

Function 'X_sampling' estimates the hidden activities of each transcription factor, according to a posterior Gaussian random process.

Usage

X_sampling(Y, C, A, X_old, base_line, C_prior, sigma_noise, sigma_A,
  sigma_baseline, sigma_X)

Arguments

Y

gene expression data matrix

C

sampled TF-gene binding network

A

sampled regulatory strength matrix

X_old

sampled transcription factor activity matrix from the previous round

base_line

sampled gene expression baseline activity

C_prior

prior TF-gene binding network

sigma_noise

variance of gene expression fitting residuals

sigma_A

variance of regulatory strength

sigma_baseline

variance of gene expression baseline activity

sigma_X

variance of transcription factor activity