C_sampling_cluster {BICORN}

cis-Regulatory Module Sampling Function

Description

Function 'C_sampling_cluster' samples a candidate cis-regulatory module for each gene, according to a discrete posterior probability distribution.

Usage

C_sampling_cluster(Y, C_old, A_old, X_old, base_line_old, C_prior, sigma_noise,
  sigma_A, sigma_baseline, sigma_X, BICORN_input)

Arguments

Y

gene expression data matrix

C_old

TF-gene binding network sampled from the previous round

A_old

regulatory strength matrix sampled from the previous round

X_old

transcription factor activity matrix sampled from the previous round

base_line_old

gene expression baseline activity sampled from the previous round

C_prior

prior TF-gene binding network

sigma_noise

variance of gene expression fitting residuals

sigma_A

variance of regulatory strength

sigma_baseline

variance of gene expression baseline activity

sigma_X

variance of transcription factor activity

BICORN_input

this list structure contains TF symbols, Gene symbols and candidate modules