A_sampling {BICORN}

Regulation Strength Sampling Function

Description

Function 'A_sampling' estimates a regulation strength for each sampled binding event in C, according to a posterior Gaussian distribution.

Usage

A_sampling(Y, C, A_old, X, base_line, C_prior, sigma_noise, sigma_A,
  sigma_baseline, sigma_X)

Arguments

Y

gene expression data matrix

C

sampled TF-gene binding network

A_old

regulatory strength sampled from the previous round, used as a prior in current function

X

sampled transcription factor activity matrix

base_line

sampled gene expression baseline activity

C_prior

prior TF-gene binding network

sigma_noise

variance of gene expression fitting residuals

sigma_A

variance of regulatory strength

sigma_baseline

variance of gene expression baseline activity

sigma_X

variance of transcription factor activity