pFstopEstop {BDP2} | R Documentation |
Determines the operating characteristics of a single-arm trial with a binary endpoint (success - failure) on the basis of analytical derivations. The design allows for stopping for futility and stopping for efficacy. Outputs are
probability of stopping for efficacy (P.effic) at each interim analysis
cumulative probability of stopping for efficacy up to the interim (P.effic.cum).
probability of futility stopping (P.futil) at each interim analysis
cumulative stopping probability up to the interim (P.futil.cum).
pFstopEstop(p, vn.int, v.critE, v.critF)
p |
true response rate |
vn.int |
vector of sample sizes at the interim analyses |
v.critE |
vector of critical boundaries for calling efficacy at the interim analyses (stop for efficacy if number of successes >= boundary) |
v.critF |
vector of critical boundaries for futility stopping at the interim analyses (stop for futility if number of successes <= boundary). Choose boundary=-1 if no stopping for futility is allowed. |
pFstopEstop(p=0.3,vn.int=c(3,9,13,18,20),v.critE=4:8, v.critF=c(0,1,2,3,3))