BDP2-package {BDP2}

Bayesian Adaptive Designs for Phase II Trials with Binary Endpoint

Description

Tools and workflow to choose design parameters in Bayesian adaptive single-arm phase II trial designs with binary endpoint (response, success) with possible stopping for efficacy and futility at interim analyses. Also contains routines to determine and visualize operating characteristics. See Kopp-Schneider et al. (2018) <doi:10.1002/bimj.201700209>.

Details

The DESCRIPTION file:

Package:	BDP2
Type:	Package
Title:	Bayesian Adaptive Designs for Phase II Trials with Binary Endpoint
Version:	0.1.3
Date:	2018-07-31
Author:	Annette Kopp-Schneider, Manuel Wiesenfarth, Ulrich Abel
Maintainer:	Manuel Wiesenfarth <[e-mail]>
Description:	Tools and workflow to choose design parameters in Bayesian adaptive single-arm phase II trial designs with binary endpoint (response, success) with possible stopping for efficacy and futility at interim analyses. Also contains routines to determine and visualize operating characteristics. See Kopp-Schneider et al. (2018) <doi:10.1002/bimj.201700209>.
License:	GPL-2
Depends:	rmarkdown, shiny, shinyBS
LazyData:	TRUE
Suggests:	knitr
VignetteBuilder:	knitr

Index of help topics:

BDP2                    Operating characteristics of a single-arm trial
                        with a binary endpoint
BDP2-package            Bayesian Adaptive Designs for Phase II Trials
                        with Binary Endpoint
BDP2_simulate           Simulated operating characteristics of a
                        single-arm trial with a binary endpoint for
                        different types of futility criteria
BDP2workflow            Shiny app for workflow
crit_general            Calculates CritBoundaries for different types
                        of futility criteria
pFstop                  Operating characteristics of a single-arm trial
                        with a binary endpoint with futility stopping
pFstopEcall             operating characteristics of a single-arm trial
                        with a binary endpoint with futility stopping
                        and calling efficacy at interim
pFstopEstop             Operating characteristics of a single-arm trial
                        with a binary endpoint with stopping for
                        futility and stopping for efficacy
plot.cE_vs_pEcall       Plot objects returned by plotBDP2()
plotBDP2                Plots

Tools and workflow to choose design parameters in Bayesian adaptive single-arm phase II trial designs with binary endpoint (response, success) with possible stopping for efficacy and futility at interim analyses. Also contains routines to determine and visualize operating characteristics.

Main functions: BDP2workflow, BDP2 and plotBDP2. BDP2workflow provides an interactive shiny app which also generates Word/pdf/html reports.

Author(s)

Annette Kopp-Schneider, Manuel Wiesenfarth, Ulrich Abel

Maintainer: Manuel Wiesenfarth <[e-mail]>

References

Kopp-Schneider, A., Wiesenfarth, M., Witt, R., Edelmann, D., Witt, O. and Abel, U. (2018).
Monitoring futility and efficacy in phase II trials with Bayesian posterior distributions - a calibration approach. Biometrical Journal, to appear.

Examples

## Not run: 
# Starts Shiny app
  BDP2workflow()

## End(Not run)