leukemia {BCDAG}

Protein levels for 68 diagnosed AML patients of subtype M2

Description

A dataset containing the protein expression levels of 18 proteins for 68 AML patients of subtype M2 (according to French-American-British (FAB) classification system). The 18 proteins selected are known to be involved in apoptosis and cell cycle regulation according to the KEGG database (Kanehisa et al. 2012). This is a subset of the dataset presented in Kornblau et al. (2009).

Usage

leukemia

Format

A data frame with 68 rows and 18 variables:

AKT

AKT protein, expression level

AKT.p308

AKT.p308 protein, expression level

AKT.p473

AKT.p473 protein, expression level

BAD

BAD protein, expression level

BAD.p112

BAD.p112 protein, expression level

BAD.p136

BAD.p136 protein, expression level

BAD.p155

BAD.p155 protein, expression level

BAX

BAX protein, expression level

BCL2

BCL2 protein, expression level

BCLXL

BCLXL protein, expression level

CCND1

CCND1 protein, expression level

GSK3

GSK3 protein, expression level

GSK3.p

GSK3.p protein, expression level

MYC

MYC protein, expression level

PTEN

PTEN protein, expression level

PTEN.p

PTEN.p protein, expression level

TP53

TP53 protein, expression level

XIAP

XIAP protein, expression level

...

Source

http://bioinformatics.mdanderson.org/Supplements/Kornblau-AML-RPPA/aml-rppa.xls

References

Kornblau, S. M., Tibes, R., Qiu, Y. H., Chen, W., Kantarjian, H. M., Andreeff, M., ... & Mills, G. B. (2009). Functional proteomic profiling of AML predicts response and survival. Blood, The Journal of the American Society of Hematology, 113(1), 154-164.

Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., & Tanabe, M. (2012). KEGG for integration and interpretation of large-scale molecular data sets. Nucleic acids research, 40(D1), D109-D114.