enbs_opt {voi}

Determine the optimum sample size in an analysis of the expected net benefit of sampling

Description

The optimum sample size for a given willingness to pay is determined either by a simple search over the supplied ENBS estimates for different sample sizes, or by a regression and interpolation method.

Usage

enbs_opt(x, pcut = 0.05, smooth = FALSE, smooth_df = NULL, keep_preds = FALSE)

Arguments

x

Data frame containing a set of ENBS estimates for different sample sizes, which will be optimised over. Usually this is for a common willingness-to-pay. The required components are enbs and n.

pcut

Cut-off probability which defines a "near-optimal" sample size. The minimum and maximum sample size for which the ENBS is within pcut (by default 5%) of its maximum value will be determined.

smooth

If TRUE, then the maximum ENBS is determined after fitting a nonparametric regression to the data frame x, which estimates and smooths the ENBS for every integer sample size in the range of x$n. The regression is done using the default settings of gam from the mgcv package.

If this is FALSE, then no smoothing or interpolation is done, and the maximum is determined by searching over the values supplied in x.

smooth_df

Basis dimension for the smooth regression. Passed as the k argument to the s() term in gam. Defaults to 6, or the number of unique sample sizes minus 1 if this is lower. Set to a higher number if you think the smoother does not capture the relation of ENBS to sample size accurately enough.

keep_preds

If TRUE and smooth=TRUE then the data frame of predictions from the smooth regression model is stored in the "preds" attribute of the result.

Value

A data frame with one row, and the following columns:

ind: An integer index identifying, e.g. the willingness to pay and other common characteristics of the ENBS estimates (e.g. incident population size, decision time horizon). This is copied from x$ind.

enbsmax: the maximum ENBS

nmax: the sample size at which this maximum is achieved

nlower: the lowest sample size for which the ENBS is within

pcut (default 5%) of its maximum value

nupper: the corresponding highest ENBS