| dag_bcell {topologyGSA} | R Documentation |
DAG representation of the B cell receptor signaling pathway
Description
The B cell receptor signaling pathway (BCR) converted to a DAG. In case of nodes with multiple genes, the most differentially expressed between groups of patients defined in y1 (acute lymphocytic leukemia patients with BCR/ABL gene rearrangement) and y2 (acute lymphocytic leukemia patients with BCR/ABL gene rearrangement) matrices.
Chiaretti S., Li X., Gentleman R., Vitale A., Wang K.S., Mandelli F., Fo R., Ritz J. (2005) Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. Clin Cancer Res, 11:7209-7219. https://aacrjournals.org/clincancerres/article/11/20/7209/188537/Gene-Expression-Profiles-of-B-lineage-Adult-Acute
Massa, M.S., Chiogna, M., Romualdi, C. (2010). Gene set analysis exploiting the topology of a pathway. BMC Systems Biology, 4:121 https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-4-121