isotitedose {titeIR}

Dose assignment for TITE-IR designs

Description

Calculate the next dose assignment for a TITE-IR design.

Usage

isotitedose(followup, DLT, assignment, obswin, doses, target = 1/3,
  safety = 0.05)

Arguments

followup

A vector of followup times

DLT

A vector of DLT results. FALSE or 0 is interpreted as no observed DLT and TRUE or 1 is interpreted as observed DLT.

assignment

a vector of dose assignments. Doses should be labeled in consecutive integers from 1 to number of dose levels.

obswin

The observation window with respect to which the MTD is defined.

doses

An integer providing the number of doses.

target

Target DLT rate

safety

The safety factor to prevent overly aggressive escalation

Value

an integer specifying the recommended dose level

See Also

isotitesim for simulations

Examples

isotitedose(followup = c(6, 5, 4, 3, 2, 1), DLT = c(0, 0, 0, 0, 0, 0),
 assignment = c(1, 1, 1, 2, 2, 2), obswin = 6, doses = 6)