| signatures {tcplfit2} | R Documentation |
Sample concentration-response data set from HTTR
Description
A data set containing 6 of the active transcriptional signatures after perturbation of MCF7 cells with Clomiphene citrate (1:1).
Usage
signatures
Format
An object of class data.frame with 6 rows and 8 columns.
Details
A data frame with 6 rows and 8 variables:
sample_id - experimental sample ID
dtxsid - DSSTox generic substance ID
name - chemical name
signature - transcriptional signature name
cutoff - the 95% confidence interval from the baseline response (2 lowest concentrations)
onesd - one standard deviation of the baseline response
conc - experimental concentrations, micromolar (uM)
resp - transcriptional signature response for each experimental concentrations, ssGSEA score
Source
References
Joshua A. Harrill, Logan J. Everett, Derik E. Haggard, Thomas Sheffield, Joseph L. Bundy, Clinton M. Willis, Russell S. Thomas, Imran Shah, Richard S. Judson, High-Throughput Transcriptomics Platform for Screening Environmental Chemicals, Toxicological Sciences, Volume 181, Issue 1, May 2021, Pages 68 - 89, https://doi.org/10.1093/toxsci/kfab009.