Ecadherin {tatest}

A microarray data

Description

Analysis of the effects of loss of E-cadherin and cell adhesion on human mammary epithelial cells

Usage

data("Ecadherin")

Format

A data frame with 5000 observations on the following 7 variables.

geneid

a factor with levels

shCntrl_rep1

a numeric vector

shCntrl_rep2

a numeric vector

shCntrl_rep3

a numeric vector

shEcad_rep1

a numeric vector

shEcad_rep2

a numeric vector

shEcad_rep3

a numeric vector

Details

Loss of the epithelial adhesion molecule E-cadherin is thought to enable metastasis by disrupting intercellular contacts-an early step in metastatic dissemination. To further investigate the molecular basis of this notion, two methods were used to inhibit E-cadherin function that distinguish between E-cadherin's cell-cell adhesion and intracellular signaling functions. While the disruption of cell-cell contacts alone does not enable metastasis, the loss of E-cadherin protein does, through induction of an epithelial-to-mesenchymal transition, invasiveness and anoikis-resistance. In addition, gene expression analysis shows that E-cadherin loss results in the induction of multiple transcription factors, at least one of which, Twist, is necessary for E-cadherin loss-induced metastasis. These findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes. This dataset consists 5000 of 22277 gene libraries, two conditions shCntrl and shEcad, each having 3 replicates. With access number GSE9691, you can obtain a whole data of 22277 gene libraries in GEO.

Examples

data(Ecadherin)