surv.exp.gt.model {survSNP}

Exponential Hazard Rates for a Genetic Risk Model

Description

This function calculates the exponential hazard rates for the conditional survival functions

Usage

surv.exp.gt.model(pilm, lm, gtprev, GRR, zmodel, interval)

Arguments

pilm

Probability that the time-to-event is greater than lm

lm

Landmark time used for powering the study

gtprev

Relative genotypic frequency

GRR

Genotype Hazard Ratio

zmodel

Genetic Risk Model (choices are "additive", "recessive" or "dominant")

interval

Interval to search for baseline hazard rate

Details

Determines the time to event distributions in the three component mixture model discussed in the reference below. It is not intended to be called directly by the user. To conduct power calculations, use sim.snp.expsurv.power or the convenience wrapper function survSNP.power.table.

Value

A vector of length three containing the exponential hazard rates

Author(s)

Kouros Owzar, Zhiguo Li, Nancy Cox, Sin-Ho Jung and Chanhee Yi

References

Kouros Owzar, Zhiguo Li, Nancy Cox and Sin-Ho Jung. Power and Sample Size Calculations for SNP Association Studies with Censored Time-to-Event Outcomes. https://onlinelibrary.wiley.com/doi/full/10.1002/gepi.21645